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Was able to control my Amazon FireStick (2nd gen) with ...
on May 26, 2018
Was able to control my Amazon FireStick (2nd gen) with Harmony 650 IR remote. DId not know this was possible since FireStick is Blue Tooth and Harmony 650 is IR. But this setup allows the FireStick to receive IR signals via the IReTV IR USB receiver (also need a USB Y cable).
For Harmony 650 choose Microsoft Xbox 360 as the device when setting up, it works for the IReTV same IR codes. The transport controls (play, pause, skip, etc), the power button, up/down, left/right arrows, OK button works perfectly. You need to remap a few buttons.
Harmony FireStick remote. Command (from XBOX 360)
Exit button Back B
Menu Button Menu/Options Y
Guide button Home Xbox Guide (not Guide command).